Sodium Bicarbonate → HCID 18788221, compound

HRID 1106940Notes

Reaction equation

HRID 1106940 reaction equation
C(OC([NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:15][CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=C(OC(C)=O)C=1)=O)CCC.[C:28](=[O:31])(O)[O-:29].[Na+].[CH:33](Cl)(Cl)Cl.[C:37](O)([C:39](F)(F)F)=O>>[C:28]([O:29][CH2:37][CH2:39][CH:15]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[NH2:8])[C:16]1[CH:17]=[CH:18][CH:23]=[CH:22][CH:21]=1)(=[O:31])[CH3:33]

Participants

4

Reactant 3

HCID 516892Sodium BicarbonateHCID 19978452Chloroform trifluoroacetic acidHCID 67718766HCID 67718766, compound

Product 1

HCID 18788221HCID 18788221, compound

Procedure

A solution of N-butyloxycarbonyl-2-(3-acetoxy1-phenylpropyl)aniline (1.39 g, 3.7 mmol) in CHCl3 -TFA (1:1/10 ml) was stirred at room temperature for 20 minutes. The reaction mixture was neutralised with saturated aqueous sodium bicarbonate solution (30 ml), extracted with DCM (3×30 ml) and the extracts dried (MgSO4). Filtration and evaporation of the solvent gave the product. (939 mg, 94%)

Workup

  1. extractionextracted with DCM (3×30 ml)
  2. dry with materialthe extracts dried (MgSO4)
  3. filtrationFiltration and evaporation of the solvent
  4. customgave the product

Sources & evidence

ORD record
ord-c6408c2608c8427e9bf5f3870612fe7f
Source dataset
uspto-grants-2000_05
Patent number
US06057311

Reaction notes

Loading…