Benzyloxycarbonyl-L-proline → HCID 15598548, compound

HRID 1106955Notes

Reaction equation

HRID 1106955 reaction equation
[NH:1]1[CH2:12][CH2:11][CH2:10][C@H:2]1[C:3]([O:5][C:6]([CH3:9])([CH3:8])[CH3:7])=[O:4].Cl.[N:14]1(C(OCC2C=CC=CC=2)=O)[CH2:21][CH2:20][CH2:19][C@H:15]1[C:16](O)=[O:17]>>[NH:14]1[CH2:21][CH2:20][CH2:19][C@H:15]1[C:16]([N:1]1[CH2:12][CH2:11][CH2:10][C@H:2]1[C:3]([O:5][C:6]([CH3:8])([CH3:9])[CH3:7])=[O:4])=[O:17]

Participants

3

Reactant 2

HCID 101987Benzyloxycarbonyl-L-prolineHCID 6453107tert-Butyl L-prolinate hydrochloride

Product 1

HCID 15598548HCID 15598548, compoundYield 99.4%

Procedure

A] Starting from H-Pro-OtBu.HCl (0.315 g, 1.5 mmoles) and Z-Pro-OH (0.397 g, 1.59 mmoles) the procedure of Example 1, C-D] was substantially applied. There was obtained 0.4 g of H-Pro-Pro-OtBu.

Sources & evidence

ORD record
ord-6fbd0fdcee3f4b9e89956bd3cc532614
Source dataset
uspto-grants-2000_05
Patent number
US06057295

Reaction notes

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