HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1107107Generated: November 3, 2026
Thiophenol → 7-Phenyl-3-phenylsulfanylheptanoic acid hydroxyamide
https://huagongshe.com/reaction/1107107
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thiophenol | HCID 7969 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | HCID 54264321 | HCID 54264321 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 7-Phenyl-3-phenylsulfanylheptanoic acid hydroxyamide | HCID 17915520 | — |
Reaction Steps
7-Phenyl-hept-2-enoic acid hydroxyamide (0.3 g; 1.4 mmol) is combined with thiophenol (0.26 g; 2.4 mmol) and piperidine (0.04 g; 0.5 mmol) in 1,4-dioxane (6 mL) and heated to 85° C. for 4 hours. After cooling, the reaction is concentrated in vacuo and purified by column chromatography using 5% MeOH/CH2Cl2 to obtain 7-phenyl-3-phenylsulfanylheptanoic acid hydroxyamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06057369 |
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| Source dataset | uspto-grants-2000_05 |
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| ORD ID | ord-7fc4d67d825842479982e4486828d6ef |
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| Source note | uspto-grants-2000_05 |
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