反应详情

温度

110 °C

A mixture of 2 g (12.53 mmol) of 4-phenylbut-2-enoic acid, 1.8 mL (14.8 mmol) of 4-methoxybenzenethiol, and 0.4 mL (3.7 mmol) of piperidine is heated at 110° C. in a bomb for 18 hours. The reaction is partitioned between ethyl ether and 1N HCl. The organic layer is dried over anhydrous MgSO4 and concentrated in vacuo. Purification by flash silica gel chromatography affords 3.07 g (82%) of 3-(4-methoxyphenylsulfanyl)-4-phenylbutyric acid as a white crystalline solid.

1. customThe reaction is partitioned between ethyl ether and 1N HCl
2. dry with materialThe organic layer is dried over anhydrous MgSO4
3. concentrationconcentrated in vacuo
4. customPurification by flash silica gel chromatography