HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 7-Methylamino-2-(2-methoxyphenyl)-4-oxo-3,4-dihydropyrimido[4,5-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 7-Methylthio-2-(2-methoxyphenyl)-4-oxo-3,4-dihydropyrimido[4,5-d]pyrimidine | HCID 135670766 | — |
| Product | 7-Methylamino-2-(2-methoxyphenyl)-4-oxo-3,4-dihydropyrimido[4,5-d]pyrimidine | HCID 136008642 | — |
Reaction Steps
In a similar manner to Example 33 reaction of 7-methylthio-2-(2-methoxyphenyl)-4-oxo-3,4-dihydropyrimido[4,5-d]pyrimidine (0.75 g) and 33% methylamine in industrial methylated spirit (25 ml) for 18 hours yielded the title compound, 0.38 g, m.p. 265-267° C. (recrystallized twice from methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06060477 |
| Source dataset | uspto-grants-2000_05 |
| ORD ID | ord-4683c94d89334623866ea9bff8290302 |
| Source note | uspto-grants-2000_05 |