Methylamine → 7-Methylamino-2-(2-methoxyphenyl)-4-oxo-3,4-dihydropyrimido[4,5-d]pyrimidine

HRID 1107320Notes

Reaction equation

HRID 1107320 reaction equation
CS[C:3]1[N:8]=[C:7]2[N:9]=[C:10]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[O:20][CH3:21])[NH:11][C:12](=[O:13])[C:6]2=[CH:5][N:4]=1.[CH3:22][NH2:23]>>[CH3:22][NH:23][C:3]1[N:8]=[C:7]2[N:9]=[C:10]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[O:20][CH3:21])[NH:11][C:12](=[O:13])[C:6]2=[CH:5][N:4]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 1356707667-Methylthio-2-(2-methoxyphenyl)-4-oxo-3,4-dihydropyrimido[4,5-d]pyrimidine

Product 1

HCID 1360086427-Methylamino-2-(2-methoxyphenyl)-4-oxo-3,4-dihydropyrimido[4,5-d]pyrimidine

Procedure

In a similar manner to Example 33 reaction of 7-methylthio-2-(2-methoxyphenyl)-4-oxo-3,4-dihydropyrimido[4,5-d]pyrimidine (0.75 g) and 33% methylamine in industrial methylated spirit (25 ml) for 18 hours yielded the title compound, 0.38 g, m.p. 265-267° C. (recrystallized twice from methanol).

Sources & evidence

ORD record
ord-4683c94d89334623866ea9bff8290302
Source dataset
uspto-grants-2000_05
Patent number
US06060477

Reaction notes

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