Hydrochloric Acid → HCID 70251311, compound

HRID 1107388Notes

Reaction equation

HRID 1107388 reaction equation
[O:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH:2]1[CH2:11][N:12]1[CH2:28][CH2:27][C:15]2([N:19]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:18][NH:17][C:16]2=[O:26])[CH2:14][CH2:13]1.[ClH:29]>C(OCC)C.ClCCl>[ClH:29].[O:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH:2]1[CH2:11][N:12]1[CH2:13][CH2:14][C:15]2([N:19]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:18][NH:17][C:16]2=[O:26])[CH2:27][CH2:28]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 9951655HCID 9951655, compound

Product 1

HCID 70251311HCID 70251311, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

3.34 g (0.01 mol) of 8-(chroman-2-yl-methyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one are dissolved in 100 ml of diethyl ether with the addition of 20 ml of dichloro-methane and treated with stirring with 6.9 ml of 1.45 N etherial hydrochloric acid with ice-cooling. After 2 h, the precipitate is filtered off with suction, washed with diethyl ether and dried in an oil pump vacuum at 60° C. 3.4 g of the title compound of m.p. 238-240° C. (capillary) are obtained.

Workup

  1. additiontreated
  2. temperaturecooling
  3. filtrationthe precipitate is filtered off with suction
  4. washwashed with diethyl ether
  5. customdried in an oil pump vacuum at 60° C

Sources & evidence

ORD record
ord-4ecf91a38cdd49b98a4439636e480495
Source dataset
uspto-grants-2000_05
Patent number
US06060482

Reaction notes

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