反应详情

3.34 g (0.01 mol) of 8-(chroman-2-yl-methyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one are dissolved in 100 ml of diethyl ether with the addition of 20 ml of dichloro-methane and treated with stirring with 6.9 ml of 1.45 N etherial hydrochloric acid with ice-cooling. After 2 h, the precipitate is filtered off with suction, washed with diethyl ether and dried in an oil pump vacuum at 60° C. 3.4 g of the title compound of m.p. 238-240° C. (capillary) are obtained.

1. additiontreated
2. temperaturecooling
3. filtrationthe precipitate is filtered off with suction
4. washwashed with diethyl ether
5. customdried in an oil pump vacuum at 60° C