HCID 9910149, compound → HCID 9949483, compound

HRID 1107397Notes

Reaction equation

HRID 1107397 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15](=[O:31])[C:16]([O:26][CH2:27][CH2:28][CH2:29][CH3:30])([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:17]([CH3:19])[CH3:18])[CH2:10][CH2:9]1)C1C=CC=CC=1>C(O)C.[OH-].[Pd+2].[OH-].[C]>[NH:8]1[CH2:9][CH2:10][CH:11]([NH:14][C:15](=[O:31])[C:16]([O:26][CH2:27][CH2:28][CH2:29][CH3:30])([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:17]([CH3:19])[CH3:18])[CH2:12][CH2:13]1

Participants

4

Reactant 1

HCID 9910149HCID 9910149, compound

Product 1

HCID 9949483HCID 9949483, compound

Reagents, catalysts & solvents 2

HCID 178502593HCID 178502593, compoundCatalystHCID 702EthanolSolvent

Procedure

To a solution of N-(1-benzyl-4-piperidinyl)-2-butoxy-3-methyl-2-phenylbutanamide (invention compound, Compound No. 4) (4.5 g, 10.6 mmole) in ethanol (60 ml) was added palladium hydroxide-carbon (1.2 g), followed by hydrogenation for 6 hours at room temperature. The catalyst was filtered off and the filtrate was removed under reduced pressure to obtain the invention compound (Compound No. 27, quantitative yield) as a colorless oil.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate was removed under reduced pressure
  3. customto obtain the invention compound (Compound No. 27, quantitative yield) as a colorless oil

Sources & evidence

ORD record
ord-d1432136f1da40b3bc9561bb679fd4b7
Source dataset
uspto-grants-2000_05
Patent number
US06060485

Reaction notes

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