Phenylacetonitrile → HCID 356429, compound

HRID 1107433Notes

Reaction equation

HRID 1107433 reaction equation
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH2:12]([C:19]#[N:20])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.CC(C)([O-])C.[K+]>CN(C=O)C>[C:13]1([CH:12]([C:2]2[CH:11]=[CH:10][C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=2)[C:19]#[N:20])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

5

Reactant 3

HCID 8794PhenylacetonitrileHCID 119282-ChloroquinolineHCID 23665647Potassium tert-butoxide

Product 1

HCID 356429HCID 356429, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The compound was prepared substantially in accordance with the procedure detailed in Example 12A, using 2-chloroquinoline (5.0 g, 30.6 mmol), benzyl cyanide (3.5 ml, 30.6 mmol) and potassium t-butoxide (6.87 g, 61.2 mmol) in 40 ml of DMF.

Workup

  1. customThe compound was prepared substantially in accordance with the procedure

Sources & evidence

ORD record
ord-b1bb1dafb0fb46bcabe4a51a2b2fe649
Source dataset
uspto-grants-2000_05
Patent number
US06060484

Reaction notes

Loading…