Ammonia → 9H-fluorene-9-carboxamide

HRID 1107435Notes

Reaction equation

HRID 1107435 reaction equation
[CH:1]1[C:13]2[CH:12]([C:14]([OH:16])=O)[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.C(Cl)(=O)C(Cl)=O.[NH3:23]>C1(C)C=CC=CC=1.CCOCC>[CH:1]1[C:13]2[CH:12]([C:14]([NH2:23])=[O:16])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

6

Reactant 3

HCID 222AmmoniaHCID 65578Oxalyl chlorideHCID 748099-Carboxyfluorene

Product 1

HCID 3450289H-fluorene-9-carboxamide

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 3283Diethyl EtherSolvent

Procedure

The compound was prepared substantially in accordance with the procedure detailed in Example 21A, using 9-fluorenecarboxylic acid (6.00 g, 28.5 mmol) and oxalyl chloride (3.5 ml, 39.9 mmol) in 30 ml of toluene to provide a clear oil that was dissolved in Et2O and treated with ammonia.

Workup

  1. customThe compound was prepared substantially in accordance with the procedure
  2. customto provide a clear oil that

Sources & evidence

ORD record
ord-69ea179f45d340048ead38ed76bad320
Source dataset
uspto-grants-2000_05
Patent number
US06060484

Reaction notes

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