2,2-Diphenylethylamine → 2,2-Diphenylethyl isocyanate

HRID 1107436Notes

Reaction equation

HRID 1107436 reaction equation
ClC(Cl)(O[C:5](=[O:11])OC(Cl)(Cl)Cl)Cl.[C:13]1([CH:19]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:20][NH2:21])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C(Cl)Cl>[C:22]1([CH:19]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:20][N:21]=[C:5]=[O:11])[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

Participants

4

Reactant 2

HCID 775752,2-DiphenylethylamineHCID 94429Triphosgene

Product 1

HCID 122583912,2-Diphenylethyl isocyanate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A suspension of triphosgene (0.78 g, 2.6 mmol) in 15 ml of CH2Cl2 was treated in small portions with 2,2-diphenylethylamine (1.54 g, 7.8 mmol) at 0° C., under N2. The reaction mixture was stirred for 30 minutes and filtered. The filtrate was then concentrated in vacuo to provide a yellow oil.

Workup

  1. filtrationfiltered
  2. concentrationThe filtrate was then concentrated in vacuo
  3. customto provide a yellow oil

Sources & evidence

ORD record
ord-8d47103ab4d14ea1a8997ec6c1a00802
Source dataset
uspto-grants-2000_05
Patent number
US06060484

Reaction notes

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