反应详情

A cold (0° C.) solution of sodium azide (1.45 g, 22.3 mmol) in 50 ml of DMF was treated with 2-chlorobenzyl chloride (2.4 ml, 18.6 mmol). The reaction mixture was stirred at room temperature for 2 days, under N2 and then partitioned between EtOAc and H2O. The resultant layers were separated and the organic layer was dried over Na2SO4, filtered and then concentrated in vacuo.

1. custompartitioned between EtOAc and H2O
2. customThe resultant layers were separated
3. dry with materialthe organic layer was dried over Na2SO4
4. filtrationfiltered
5. concentrationconcentrated in vacuo