4-Oxo-1-phenylcyclohexanenitrile → 4-Hydroxy-1-phenylcyclohexane-1-carbonitrile

HRID 1107441Notes

Reaction equation

HRID 1107441 reaction equation
[C:1]([C:3]1([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:8][CH2:7][C:6](=[O:9])[CH2:5][CH2:4]1)#[N:2].[BH4-].[Na+]>CO>[C:1]([C:3]1([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:8][CH2:7][CH:6]([OH:9])[CH2:5][CH2:4]1)#[N:2]

Participants

4

Reactant 2

HCID 912824-Oxo-1-phenylcyclohexanenitrileHCID 4311764Sodium borohydride

Product 1

HCID 124536734-Hydroxy-1-phenylcyclohexane-1-carbonitrile

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A cold (0° C.) solution of 4-cyano-4-phenylcyclohexanone (5.0 g, 25.1 mmol) in 30 ml of MeOH was treated with sodium borohydride (1.14 g, 30.1 mmol). The reaction mixture was stirred for 2 hours at room temperature and then concentrated in vacuo.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-cc8638597dbb48998b118474e48653ff
Source dataset
uspto-grants-2000_05
Patent number
US06060484

Reaction notes

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