反应详情

3 g (9.82 mmol) of 2,3-dimethyl-7-(2-[tert-butyldimethylsilyloxy]-1-hydroxyethyl)benzofuran, 50 ml of ethyl ether and 2.2 ml (15.7 mmol) of triethylamine are introduced into a 100 ml round-bottomed flask. The mixture is cooled to -30° C. by a bath of dry ice in acetone and 1.24 ml (15.7 mmol) of mesyl chloride are added. The cooling bath is removed and the reaction mixture is allowed to return to room temperature over 30 minutes. 200 ml of water are added and extraction is carried out with ethyl ether (3×150 ml). The organic phases are combined, dried over magnesium sulphate and concentrated. The residue is transferred, without additional purification, to a 100 ml three-necked flask equipped with a reflux condenser. 20 ml (190 mmol) of diethylamine and 3 ml of chloroform are added and the reaction mixture is heated at reflux for 16 hours. The reaction mixture is cooled to room temperature and concentrated under vacuum, 150 ml of water are added and extraction is carried out with ethyl ether (3×200 ml). The organic phases are combined, dried over magnesium sulphate and concentrated under vacuum. The residue is purified by chromatography on a silica column (elution solvent: 10% methanol in dichloromethane). 2.77 g (Yield 78%) of 2,3-dimethyl-7-(1-diethylamino-2-[tert-butyldimethylsilyloxy] ethyl)-benzofuran are obtained in the form of an oil. (0.5 g of unreacted 2,3-dimethyl-7-(2-[tert-butyldimethylsilyloxy]-1-hydroxyethyl)benzofuran is recovered.

1. additionare added
2. customThe cooling bath is removed
3. addition200 ml of water are added
4. extractionextraction
5. dry with materialdried over magnesium sulphate
6. concentrationconcentrated
7. customThe residue is transferred, without additional purification, to a 100 ml three-necked flask
8. customequipped with a reflux condenser
9. temperaturethe reaction mixture is heated
10. temperatureat reflux for 16 hours
11. concentrationconcentrated under vacuum, 150 ml of water
12. additionare added
13. extractionextraction
14. dry with materialdried over magnesium sulphate
15. concentrationconcentrated under vacuum
16. customThe residue is purified by chromatography on a silica column (elution solvent: 10% methanol in dichloromethane)