反应详情

温度

90 °C

Piperidine hydrochloride (3.648 g, 30 mmol) was stirred in a mixture of 4.0 mL of water and 4.146 g of ground potassium carbonate. This mixture was heated to 90° C. and cyclohexene oxide (1.01 mL, 10 mmol) was added. The resulting mixture was heated at 100° C. for 18 hours. The reaction was cooled then filtered to remove carbonate salts. The filter cake was washed with 25 mL of diethyl ether and 50 mL of ethyl acetate. The filtrate and washings were combined and washed with brine (2×20 mL), dried over magnesium sulfate, filtered, and evaporated to give 1.875 g (>100%) of the title compound which was used without further purification. 1H NMR consistent with desired product.

1. temperatureThe resulting mixture was heated at 100° C. for 18 hours
2. temperatureThe reaction was cooled
3. filtrationthen filtered
4. customto remove carbonate salts
5. washThe filter cake was washed with 25 mL of diethyl ether and 50 mL of ethyl acetate
6. washwashed with brine (2×20 mL)
7. dry with materialdried over magnesium sulfate
8. filtrationfiltered
9. customevaporated