Ethanethiol → HCID 23512909, compound

HRID 1107584Notes

Reaction equation

HRID 1107584 reaction equation
C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11](=[O:27])[C:12]3[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH:20]4[CH2:25][CH2:24][CH2:23][CH2:22][N:21]4[CH3:26])=[CH:14][CH:13]=3)=[C:9]([C:28]3[CH:33]=[CH:32][C:31]([O:34]C)=[CH:30][CH:29]=3)[S:8][C:7]=2[CH:36]=1.C(S)C.[Cl-].[Al+3].[Cl-].[Cl-]>>[OH:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11](=[O:27])[C:12]3[CH:13]=[CH:14][C:15]([O:18][CH2:19][CH:20]4[CH2:25][CH2:24][CH2:23][CH2:22][N:21]4[CH3:26])=[CH:16][CH:17]=3)=[C:9]([C:28]3[CH:29]=[CH:30][C:31]([OH:34])=[CH:32][CH:33]=3)[S:8][C:7]=2[CH:36]=1

Participants

4

Reactant 3

HCID 6343EthanethiolHCID 6451240Aluminum(III) ChlorideHCID 9892244HCID 9892244, compound

Product 1

HCID 23512909HCID 23512909, compoundYield 61%

Procedure

6-Methoxy-2-(4-methoxyphenyl)-3-(4-[(1-methylpiperidin-2-yl)methoxy]benzoyl)benzo[b]thiophene (339 mg, 0.676 mmol), ethane thiol (8.75 mmol), and aluminum chloride (541 mg, 4.06 mmol) were converted to 195 mg (61%) of the title compound by the procedure of Example 16. MS(FD) 473(M+). IR (CHCl3) ν max 3414, 3179, 1605, 1468, 1261, 1170.

Sources & evidence

ORD record
ord-2728fbbbd9304d82bc7b6685472ad5cb
Source dataset
uspto-grants-2000_05
Patent number
US06060488

Reaction notes

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