HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanethiol → 6-Hydroxy-2-(4-Hydroxyphenyl)-3-(4-[1-Benzylpyrrolidin-3-oxy]benzoyl)benzo[b]thiophene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanethiol | HCID 6343 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | 6-Methoxy-2-(4-Methoxyphenyl)-3-(4-[1-Benzylpyrrolidin-3-oxy]benzoyl)benzo[b]thiophene | HCID 9915517 | — |
| Product | 6-Hydroxy-2-(4-Hydroxyphenyl)-3-(4-[1-Benzylpyrrolidin-3-oxy]benzoyl)benzo[b]thiophene | HCID 18787298 | 38% |
Reaction Steps
6-Methoxy-2-(4-methoxyphenyl)-3-(4-[1-benzylpyrrolidin-3-oxy]benzoyl)benzo[b]thiophene (1.57 g, 2.86 mmol), ethane thiol (14.3 mmol), and aluminum chloride (2.29 g, 17.2 mmol) were converted to 566 mg (38%) of the title compound by the procedure of Example 16. MS(FD) 521(M+). IR (CHCl3) ν max 3300, 3027, 3012, 2981, 1732, 1599, 1469, 1257, 1167.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06060488 |
| Source dataset | uspto-grants-2000_05 |
| ORD ID | ord-52921904315942d8af1eff4a0e86650d |
| Source note | uspto-grants-2000_05 |