Ethanethiol → HCID 12992508, compound

HRID 1107588Notes

Reaction equation

HRID 1107588 reaction equation
C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11](=[O:27])[C:12]3[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH:20]4[CH2:25][CH2:24][CH2:23][N:22]([CH3:26])[CH2:21]4)=[CH:14][CH:13]=3)=[C:9]([C:28]3[CH:33]=[CH:32][C:31]([O:34]C)=[CH:30][CH:29]=3)[S:8][C:7]=2[CH:36]=1.C(S)C.[Cl-].[Al+3].[Cl-].[Cl-]>>[OH:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11](=[O:27])[C:12]3[CH:13]=[CH:14][C:15]([O:18][CH2:19][CH:20]4[CH2:25][CH2:24][CH2:23][N:22]([CH3:26])[CH2:21]4)=[CH:16][CH:17]=3)=[C:9]([C:28]3[CH:29]=[CH:30][C:31]([OH:34])=[CH:32][CH:33]=3)[S:8][C:7]=2[CH:36]=1

Participants

4

Reactant 3

HCID 6343EthanethiolHCID 6451240Aluminum(III) ChlorideHCID 9870649HCID 9870649, compound

Product 1

HCID 12992508HCID 12992508, compoundYield 54%

Procedure

6-Methoxy-2-(4-methoxyphenyl)-3-(4-[(1-methylpiperidin-3-yl)methoxy]benzoyl)benzo[b]thiophene (878 mg, 1.75 mmol), ethane thiol (8.75 mmol), and aluminum chloride (1.40 g, 10.S mmol) were converted to 447 mg (54%) of the title compound by the procedure of Example 16. MS(FD) 473(M+). IR (CHCl3) ν max 3205, 2954, 1599, 1467, 1266, 1171.

Sources & evidence

ORD record
ord-0ef6ae30be59453aa48c25f52a7b936e
Source dataset
uspto-grants-2000_05
Patent number
US06060488

Reaction notes

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