Ethanethiol → HCID 18787302, compound

HRID 1107589Notes

Reaction equation

HRID 1107589 reaction equation
C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11](=[O:26])[C:12]3[CH:17]=[CH:16][C:15]([O:18][CH:19]4[CH2:24][CH2:23][CH2:22][N:21]([CH3:25])[CH2:20]4)=[CH:14][CH:13]=3)=[C:9]([C:27]3[CH:32]=[CH:31][C:30]([O:33]C)=[CH:29][CH:28]=3)[S:8][C:7]=2[CH:35]=1.C(S)C.[Cl-].[Al+3].[Cl-].[Cl-]>>[OH:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11](=[O:26])[C:12]3[CH:13]=[CH:14][C:15]([O:18][CH:19]4[CH2:24][CH2:23][CH2:22][N:21]([CH3:25])[CH2:20]4)=[CH:16][CH:17]=3)=[C:9]([C:27]3[CH:32]=[CH:31][C:30]([OH:33])=[CH:29][CH:28]=3)[S:8][C:7]=2[CH:35]=1

Participants

4

Reactant 3

HCID 6343EthanethiolHCID 6451240Aluminum(III) ChlorideHCID 9957112HCID 9957112, compound

Product 1

HCID 18787302HCID 18787302, compoundYield 72.2%

Procedure

6-Methoxy-2-(4-methoxyphenyl)-3-(4-[1-methylpiperidin-3-oxy]benzoyl)benzo[b]thiophene (310 mg, 0.636 mmol), ethane thiol (3.18 mmol), and aluminum chloride (508 mg, 3.81 mmol) were converted to 211 mg (72%) of the title compound by the procedure of Example 16. MS(FD) 460(M+). IR (CHCl3) ν max 3400, 3149, 2947, 1598, 1467, 1254, 1164.

Sources & evidence

ORD record
ord-134a53b63d2041e2aad864aaf002f391
Source dataset
uspto-grants-2000_05
Patent number
US06060488

Reaction notes

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