Ethanethiol → HCID 18787292, compound

HRID 1107590Notes

Reaction equation

HRID 1107590 reaction equation
C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11](=[O:27])[C:12]3[CH:17]=[CH:16][C:15]([O:18][CH:19]4[CH2:24][CH2:23][CH2:22][NH:21][CH:20]4[CH2:25][CH3:26])=[CH:14][CH:13]=3)=[C:9]([C:28]3[CH:33]=[CH:32][C:31]([O:34]C)=[CH:30][CH:29]=3)[S:8][C:7]=2[CH:36]=1.C(S)C.[Cl-].[Al+3].[Cl-].[Cl-]>>[OH:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11](=[O:27])[C:12]3[CH:13]=[CH:14][C:15]([O:18][CH:19]4[CH2:24][CH2:23][CH2:22][NH:21][CH:20]4[CH2:25][CH3:26])=[CH:16][CH:17]=3)=[C:9]([C:28]3[CH:29]=[CH:30][C:31]([OH:34])=[CH:32][CH:33]=3)[S:8][C:7]=2[CH:36]=1

Participants

4

Reactant 3

HCID 6343EthanethiolHCID 6451240Aluminum(III) ChlorideHCID 18787305HCID 18787305, compound

Product 1

HCID 18787292HCID 18787292, compoundYield 90%

Procedure

6-Methoxy-2-(4-methoxyphenyl)-3-(4-[2-ethylpiperidin-3-oxy]benzoyl)benzo[b]thiophene (226 mg, 0.451 mmol), ethane thiol (2.25 mmol), and aluminum chloride (360 mg, 2.70 mmol) were converted to 192 mg (90%) of the title compound by the procedure of Example 16. MS(FD) 474(M+). IR (CHCl3) ν max 3380, 2970, 1597, 1467, 1255, 1165.

Sources & evidence

ORD record
ord-e7ab845db0774bd19f202d560ba08c8e
Source dataset
uspto-grants-2000_05
Patent number
US06060488

Reaction notes

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