HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanethiol → 6-Hydroxy-2-(4-Hydroxyphenyl)-3-(4-[2-Pyrrolidin-1-ylcyclohexoxy]benzoyl)benzo[b]thiophene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanethiol | HCID 6343 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | 6-Methoxy-2-(4-Methoxyphenyl)-3-(4-[2-Pyrrolidin-1-ylcyclohexoxy]benzoyl)benzo[b]thiophene | HCID 9958990 | — |
| Product | 6-Hydroxy-2-(4-Hydroxyphenyl)-3-(4-[2-Pyrrolidin-1-ylcyclohexoxy]benzoyl)benzo[b]thiophene | HCID 18787294 | 92.6% |
Reaction Steps
6-Methoxy-2-(4-methoxyphenyl)-3-(4-[2-pyrrolidin-1-ylcyclohexoxy]benzoyl)benzo[b]thiophene (610 mg, 1.10 mmol), ethane thiol (5.50 mmol), and aluminum chloride (880 mg, 6.60 mmol) were converted to 523 mg (90%) of the title compound by the procedure of Example 16. MS(FD) 528(M+). IR (CHCl3) ν max 3377, 2934, 2857, 1595, 1467, 1258, 1164.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06060488 |
| Source dataset | uspto-grants-2000_05 |
| ORD ID | ord-70e7b1a576664351a60eb5e12f6eb9bf |
| Source note | uspto-grants-2000_05 |