Nitric Acid → HCID 178518238, compound

HRID 1107604Notes

Reaction equation

HRID 1107604 reaction equation
CC[C:3]1(C2C=CC=CC=2)[C:9](=O)[NH:8][CH2:7][NH:6][C:4]1=O.[N+:17]([O-])([OH:19])=[O:18].[OH-:21].[Na+]>S(=O)(=O)(O)O>[N+:17]([C:9]1[CH:3]=[CH:4][NH:6][C:7](=[O:21])[N:8]=1)([O-:19])=[O:18]

Participants

5

Reactant 3

HCID 944Nitric AcidHCID 4909PrimidoneHCID 14798Sodium Hydroxide

Product 1

HCID 178518238HCID 178518238, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent2×

Procedure

Primidone, 1.60 g, was dissolved with stirring in 8 ml concentrated sulfuric acid and cooled in ice. A cold solution of 485 μl concentrated nitric acid in 2 ml concentrated sulfuric acid was added over a period of 10 minutes. After 2 hours at 0° C. the reaction mixture was poured into ice water neutralized with cold sodium hydroxide. The precipitate was collected, washed with water and dried in vacuo affording 1.79 g white solid.

Workup

  1. temperaturecooled in ice
  2. customThe precipitate was collected
  3. washwashed with water
  4. customdried in vacuo

Sources & evidence

ORD record
ord-342f3fd5b9184653b24d8745d572a757
Source dataset
uspto-grants-2000_05
Patent number
US06060598

Reaction notes

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