Sodium Iodide → HCID 178433536, compound

HRID 1107697Notes

Reaction equation

HRID 1107697 reaction equation
[C:1]([C:4]([O:7]/[N:8]=[C:9](/[C:38]1[N:39]=[C:40]([NH:43]C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[S:41][CH:42]=1)\[C:10]([NH:12][C@@H:13]1[C:36](=[O:37])[N:15]2[C:16]([C:24]([O:26]CC3C=CC(OC)=CC=3)=[O:25])=[C:17](/[CH:20]=[CH:21]\[CH2:22]Cl)[CH2:18][S:19][C@H:14]12)=[O:11])([CH3:6])[CH3:5])([OH:3])=[O:2].[I-].[Na+].[CH3:65][N:66]([CH2:68][C:69]1[S:73][CH:72]=[N:71][C:70]=1[CH3:74])[CH3:67]>>[NH2:43][C:40]1[S:41][CH:42]=[C:38](/[C:9](=[N:8]/[O:7][C:4]([C:1]([OH:3])=[O:2])([CH3:5])[CH3:6])/[C:10]([NH:12][C@@H:13]2[C:36](=[O:37])[N:15]3[C:16]([C:24]([O-:26])=[O:25])=[C:17](/[CH:20]=[CH:21]/[CH2:22][N+:66]([CH3:67])([CH3:65])[CH2:68][C:69]4[S:73][CH:72]=[N:71][C:70]=4[CH3:74])[CH2:18][S:19][C@H:14]23)=[O:11])[N:39]=1

Participants

4

Reactant 3

HCID 5238Sodium IodideHCID 18785536HCID 18785536, compoundHCID 178491512HCID 178491512, compound

Product 1

HCID 178433536HCID 178433536, compoundYield 16.5%

Procedure

p-methoxybenzyl 7β-[(Z)-2-(2-carboxyprop-2-oxyimino)-2-(2-tritylaminothiazol-4-yl)acetamido]-3-[(Z)-3-chloro-1-propen-1-yl]3-cephem-4-carboxylate(1.5 g), sodium iodide (0.75 g) and 5-dimethylam-inomethyl-4-methylthiazole(0.31 g) were reacted in the same manner as described in Example 1 to obtain the target product(180 mg).

Sources & evidence

ORD record
ord-d9a33afbeaa8490bb235d4b19bbcf4c8
Source dataset
uspto-grants-2000_05
Patent number
US06063778

Reaction notes

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