Sodium Iodide → HCID 139844125, compound

HRID 1107698Notes

Reaction equation

HRID 1107698 reaction equation
[F:1][CH2:2][CH2:3][O:4]/[N:5]=[C:6](/[C:35]1[N:36]=[C:37]([NH:40]C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[S:38][CH:39]=1)\[C:7]([NH:9][C@@H:10]1[C:33](=[O:34])[N:12]2[C:13]([C:21]([O:23]CC3C=CC(OC)=CC=3)=[O:22])=[C:14](/[CH:17]=[CH:18]\[CH2:19]Cl)[CH2:15][S:16][C@H:11]12)=[O:8].[I-].[Na+].[CH3:62][N:63]([CH2:65][C:66]1[S:70][CH:69]=[N:68][C:67]=1[CH3:71])[CH3:64]>>[NH2:40][C:37]1[S:38][CH:39]=[C:35](/[C:6](=[N:5]/[O:4][CH2:3][CH2:2][F:1])/[C:7]([NH:9][C@@H:10]2[C:33](=[O:34])[N:12]3[C:13]([C:21]([O-:23])=[O:22])=[C:14](/[CH:17]=[CH:18]/[CH2:19][N+:63]([CH3:64])([CH3:62])[CH2:65][C:66]4[S:70][CH:69]=[N:68][C:67]=4[CH3:71])[CH2:15][S:16][C@H:11]23)=[O:8])[N:36]=1

Participants

4

Reactant 3

HCID 5238Sodium IodideHCID 18785536HCID 18785536, compoundHCID 139844128HCID 139844128, compound

Product 1

HCID 139844125HCID 139844125, compoundYield 32.3%

Procedure

p-methoxybenzyl 7β[(Z)-2-fluoroethoxyimino-2-(2-tritylaminothiazol-4-yl)acetamido]3-[(Z)-3-chloro-1-propen-1-yl]3-cephem-4-carboxylate (1.3 g), sodium iodide(0.68 g) and 5-dimethylaminomethyl-4-methylthiazole(0.27 g) were reacted in the same manner as described in Example 1 to obtain the target product (300 mg).

Sources & evidence

ORD record
ord-50900bcf9804481890ba4ac952a7a2ec
Source dataset
uspto-grants-2000_05
Patent number
US06063778

Reaction notes

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