(4-Chloro-2-fluorophenyl)methanol → 1-(2-Butenyl)-7-(4-chloro-2-fluorobenzyloxy)-2,3-dimethylpyrrolo[2,3-d]pyridazine

HRID 1107776Notes

Reaction equation

HRID 1107776 reaction equation
[CH2:1]([N:5]1[C:9]2=[C:10](Cl)[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH3:15])=[C:6]1[CH3:16])[CH:2]=[CH:3][CH3:4].[Cl:17][C:18]1[CH:25]=[CH:24][C:21]([CH2:22][OH:23])=[C:20]([F:26])[CH:19]=1>>[CH2:1]([N:5]1[C:9]2=[C:10]([O:23][CH2:22][C:21]3[CH:24]=[CH:25][C:18]([Cl:17])=[CH:19][C:20]=3[F:26])[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH3:15])=[C:6]1[CH3:16])[CH:2]=[CH:3][CH3:4]

Participants

3

Reactant 2

HCID 2773609(4-Chloro-2-fluorophenyl)methanolHCID 537196241-(2-Butenyl)-7-chloro-2,3-dimethylpyrrolo[2,3-d]pyridazine

Product 1

HCID 541691001-(2-Butenyl)-7-(4-chloro-2-fluorobenzyloxy)-2,3-dimethylpyrrolo[2,3-d]pyridazineYield 63.8%

Procedure

The title compound (cis/trans=24:76) was prepared as a white powder in 63.8% yield in a similar procedure to that described in Example 1 by using using 1-(2-butenyl)-7-chloro-2,3-dimethylpyrrolo[2,3-d]pyridazine (cis/trans=24/76) and 4-chloro-2-fluorobenzyl alcohol.

Sources & evidence

ORD record
ord-6e79ae1002d244bcb6e57d10784ff960
Source dataset
uspto-grants-2000_05
Patent number
US06063782

Reaction notes

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