(2,4-Difluorophenyl)methanethiol → 1-(2-Butenyl)-7-(2,4-difluorobenzylthio)-2,3-dimethylpyrrolo[2,3-d]pyridazine

HRID 1107779Notes

Reaction equation

HRID 1107779 reaction equation
[CH2:1]([N:5]1[C:9]2=[C:10](Cl)[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH3:15])=[C:6]1[CH3:16])[CH:2]=[CH:3][CH3:4].[F:17][C:18]1[CH:23]=[C:22]([F:24])[CH:21]=[CH:20][C:19]=1[CH2:25][SH:26]>>[CH2:1]([N:5]1[C:9]2=[C:10]([S:26][CH2:25][C:19]3[CH:20]=[CH:21][C:22]([F:24])=[CH:23][C:18]=3[F:17])[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH3:15])=[C:6]1[CH3:16])[CH:2]=[CH:3][CH3:4]

Participants

3

Reactant 2

HCID 2761425(2,4-Difluorophenyl)methanethiolHCID 537196241-(2-Butenyl)-7-chloro-2,3-dimethylpyrrolo[2,3-d]pyridazine

Product 1

HCID 542685331-(2-Butenyl)-7-(2,4-difluorobenzylthio)-2,3-dimethylpyrrolo[2,3-d]pyridazineYield 39%

Procedure

The title compound (cis/trans=16:84) was prepared as pale brown crystals in 39.0% yield in a similar procedure to that described in Example 1 by using 1-(2-butenyl)-7-chloro-2,3-dimethylpyrrolo[2,3-d]pyridazine (cis/trans=22/78) and 2,4-difluorophenylmethanethiol.

Sources & evidence

ORD record
ord-fb58787a2d424ef18e857549fd475069
Source dataset
uspto-grants-2000_05
Patent number
US06063782

Reaction notes

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