2-Pyridinemethanethiol → 1-(2-Butenyl)-2,3-dimethyl-7-(2-pyridylmethylthio)-pyrrolo[2,3-d]pyridazine

HRID 1107782Notes

Reaction equation

[CH2:1]([N:5]1[C:9]2=[C:10](Cl)[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH3:15])=[C:6]1[CH3:16])[CH:2]=[CH:3][CH3:4].[N:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[CH2:23][SH:24]>>[CH2:1]([N:5]1[C:9]2=[C:10]([S:24][CH2:23][C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][N:17]=3)[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH3:15])=[C:6]1[CH3:16])[CH:2]=[CH:3][CH3:4]

Participants

Reactant 2

HCID 2560712-Pyridinemethanethiol

HCID 537196241-(2-Butenyl)-7-chloro-2,3-dimethylpyrrolo[2,3-d]pyridazine

Product 1

HCID 539309881-(2-Butenyl)-2,3-dimethyl-7-(2-pyridylmethylthio)-pyrrolo[2,3-d]pyridazineYield 64.8%

Procedure

The title compound (cis/trans=20/80) was prepared as a yellow oil in 64.8% yield in a similar procedure to that described in Example 1 by using 1-(2-butenyl)-7-chloro-2,3-dimethylpyrrolo[2,3-d]pyridazine (cis/trans-22/78) and 2-pyridylmethanethiol.

Sources & evidence

ORD record: ord-57299c1656ba4789957b039989f33ab1
Source dataset: uspto-grants-2000_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06063782

Reaction notes

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