2,4-Difluorobenzyl alcohol → 7-(2,4-Difluorobenzyloxy)-2,3-dimethyl-1-(2-methylcyclopropylmethyl)pyrrolo[2,3-d]pyridazine

HRID 1107786Notes

Reaction equation

HRID 1107786 reaction equation
Cl[C:2]1[N:3]=[N:4][CH:5]=[C:6]2[C:10]([CH3:11])=[C:9]([CH3:12])[N:8]([CH2:13][CH:14]3[CH2:16][CH:15]3[CH3:17])[C:7]=12.[F:18][C:19]1[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:20]=1[CH2:21][OH:22]>>[F:18][C:19]1[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:20]=1[CH2:21][O:22][C:2]1[N:3]=[N:4][CH:5]=[C:6]2[C:10]([CH3:11])=[C:9]([CH3:12])[N:8]([CH2:13][CH:14]3[CH2:16][CH:15]3[CH3:17])[C:7]=12

Participants

3

Reactant 2

HCID 918672,4-Difluorobenzyl alcoholHCID 227196507-Chloro-2,3-dimethyl-1-(2-methylcyclopropylmethyl)pyrrolo[2,3-d]pyridazine

Product 1

HCID 187560697-(2,4-Difluorobenzyloxy)-2,3-dimethyl-1-(2-methylcyclopropylmethyl)pyrrolo[2,3-d]pyridazineYield 63.8%

Procedure

The title compound (trans) was prepared as a white powder in 63.8% yield in a similar procedure to that described in Example 1 by using 7-chloro-2,3-dimethyl-1-(2-methylcyclopropylmethyl)pyrrolo[2,3-d]pyridazine and 2,4-difluorobenzyl alcohol.

Sources & evidence

ORD record
ord-6eeb191e73294f8fad23f4afd52c0d70
Source dataset
uspto-grants-2000_05
Patent number
US06063782

Reaction notes

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