Bromomethylcyclopropane → HCID 18785661, compound

HRID 1107821Notes

Reaction equation

HRID 1107821 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([C:12]2[NH:16][C:15]([CH3:17])=[C:14]([CH3:18])[CH:13]=2)=[O:11])=[CH:4][CH:3]=1.[CH:19]1([CH2:22]Br)[CH2:21][CH2:20]1>>[CH:19]1([CH2:22][N:16]2[C:12]([C:10](=[O:11])[CH2:9][CH2:8][C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)=[CH:13][C:14]([CH3:18])=[C:15]2[CH3:17])[CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 81503BromomethylcyclopropaneHCID 18785698HCID 18785698, compound

Product 1

HCID 18785661HCID 18785661, compoundYield 64.8%

Procedure

The title compound was prepared as a pale yellow oil in 64.8% yield in a similar procedure to that described in Referential Example 97 by using 5-[3-(4-fluorophenyl)propionyl]-2,3-dimethylpyrrole and cyclopropylmethyl bromide.

Sources & evidence

ORD record
ord-71166ea83e8340188c351935e951fad9
Source dataset
uspto-grants-2000_05
Patent number
US06063782

Reaction notes

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