Bromomethylcyclopropane → HCID 18785646, compound

HRID 1107829Notes

Reaction equation

HRID 1107829 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][C:11]([C:13]1[NH:17][C:16]([CH3:18])=[C:15]([CH3:19])[CH:14]=1)=[O:12].[CH:20]1([CH2:23]Br)[CH2:22][CH2:21]1>>[CH:20]1([CH2:23][N:17]2[C:13]([C:11](=[O:12])[CH2:10][CH2:9][C:3]3[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=3[F:1])=[CH:14][C:15]([CH3:19])=[C:16]2[CH3:18])[CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 81503BromomethylcyclopropaneHCID 18785654HCID 18785654, compound

Product 1

HCID 18785646HCID 18785646, compound

Procedure

The title compound was prepared as a yellow solid in 85.16 yield in a similar procedure to that described in Referential Example 97 by using 5-[3-(2,4-difluorophenyl)propionyl]-2,3-dimethylpyrrole and cyclopropylmethyl bromide.

Workup

  1. customyield in a similar procedure to

Sources & evidence

ORD record
ord-4f2dced8f7ab46f1a9a0621b56fa4963
Source dataset
uspto-grants-2000_05
Patent number
US06063782

Reaction notes

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