Trifluoroacetic acid → HCID 23301372, compound

HRID 1107855Notes

Reaction equation

HRID 1107855 reaction equation
FC(F)(F)C(O)=O.[C:8]1([C:14]2[N:15]([CH2:29][C:30]([O:32]C(C)(C)C)=[O:31])[C:16]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[C:17]3[C:22]=2[CH2:21][CH:20]=[CH:19][CH2:18]3)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>ClCCl>[C:23]1([C:16]2[N:15]([CH2:29][C:30]([OH:32])=[O:31])[C:14]([C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=3)=[C:22]3[C:17]=2[CH2:18][CH:19]=[CH:20][CH2:21]3)[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 23301391HCID 23301391, compound

Product 1

HCID 23301372HCID 23301372, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

5 ml of trifluoroacetic acid are added at 0° C. to a solution of 5 g of the compound of Step A in 50 ml of anhydrous dichloromethane. After reaction for 12 hours at ambient temperature, the reaction mixture is concentrated in vacuo and the residue obtained is rinsed with ether to allow isolation of the expected product.

Workup

  1. customAfter reaction for 12 hours at ambient temperature
  2. concentrationthe reaction mixture is concentrated in vacuo
  3. customthe residue obtained
  4. washis rinsed with ether

Sources & evidence

ORD record
ord-aaa30bd16f364c6898a2b71625242ac7
Source dataset
uspto-grants-2000_05
Patent number
US06063804

Reaction notes

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