Aspirin → HCID 178475383, compound

HRID 1107856Notes

Reaction equation

HRID 1107856 reaction equation
[C:1]([O:4][C:5]1[C:6](=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:7]([OH:9])=[O:8])(=[O:3])[CH3:2].[CH3:14][NH:15][C:16]([NH2:18])=[NH:17]>O.[OH-].[Na+]>[C:1]([O:4][C:5]1[C:6](=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:7]([OH:9])=[O:8])(=[O:3])[CH3:2].[CH3:14][NH:15][C:16]([NH2:18])=[NH:17]

Participants

5

Reactant 2

HCID 2244AspirinHCID 178485088HCID 178485088, compound

Product 1

HCID 178475383HCID 178475383, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 14798Sodium HydroxideSolvent

Procedure

450 mg (2.5 mmol) acetylsalicylic acid are dissolved in 20 ml water containing 2.5 ml of 1N NaOH. Next 237.8 mg methylguanidine chlorohydrate in 10 ml water is added. The mixture is agitated for 15 minutes. A clear solution is obtained. Lyophilizationfurnishes a white powder (m.p.=153° C.). NMR-1H (100 MHz, D2O): 7.3-6.6 (m, 4H, aromatic); 2.3 (s, 3H, NCH3); 1.8 (s, 3H, COCH3).

Workup

  1. customA clear solution is obtained

Sources & evidence

ORD record
ord-bbd3ce7dd4c14299988c364e611688a7
Source dataset
uspto-grants-2000_05
Patent number
US06063807

Reaction notes

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