Aspirin → HCID 178475383, compound

Participants

Reaction Steps

450 mg (2.5 mmol) acetylsalicylic acid are dissolved in 20 ml water containing 2.5 ml of 1N NaOH. Next 237.8 mg methylguanidine chlorohydrate in 10 ml water is added. The mixture is agitated for 15 minutes. A clear solution is obtained. Lyophilizationfurnishes a white powder (m.p.=153° C.). NMR-1H (100 MHz, D2O): 7.3-6.6 (m, 4H, aromatic); 2.3 (s, 3H, NCH3); 1.8 (s, 3H, COCH3).

Provenance & Evidence