2-Methoxyaniline → HCID 18782298, compound

HRID 1107991Notes

Reaction equation

HRID 1107991 reaction equation
[CH3:1][O:2][C:3]1[CH:9]=[CH:8][CH:7]=[CH:6][C:4]=1[NH2:5].[F:10][C:11]([F:19])([F:18])[C:12](=[O:17])[CH2:13][C:14](=O)[CH3:15]>C(OCC)C>[CH3:1][O:2][C:3]1[CH:9]=[CH:8][CH:7]=[CH:6][C:4]=1[N:5]=[C:14]([CH3:15])[CH2:13][C:12](=[O:17])[C:11]([F:19])([F:18])[F:10]

Participants

4

Reactant 2

HCID 70002-MethoxyanilineHCID 739431,1,1-Trifluoro-2,4-pentanedione

Product 1

HCID 18782298HCID 18782298, compoundYield 99.1%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
102.5 °C

Procedure

A mixture of 28.4 g (0.23 mol) of 2-methoxyaniline and 43.2 g (0.28 mol) of 1,1,1-trifluoro-2,4-pentanedione is prepared and heated at 100-105° C. for 1 h, with stirring. After cooling, the reaction mixture is redissolved in ethyl ether and the solution obtained is dried over sodium sulfate and then concentrated under reduced pressure to give 59.1 g of the expected product in the form of a beige solid (yield=99%).

Workup

  1. customis prepared
  2. temperatureAfter cooling
  3. customthe solution obtained
  4. dry with materialis dried over sodium sulfate
  5. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-9f9b6e42beca40f29cd5b0526f8bf526
Source dataset
uspto-grants-2000_05
Patent number
US06063791

Reaction notes

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