反应详情

The product of Step 4 (0.5 g) was treated with trifluoroacetic acid (10 mL) and heated at reflux temperature for 45 minutes. The reaction mixture was cooled, diluted with toluene (40 mL) and evaporated. This procedure was repeated two more times. The residue was treated with CH2Cl2 (70 mL) and adjusted to alkaline pH via addition of NH4OH solution. The organic layer was separated, dried over MgSO4, filtered and evaporated to give 4-(2-methylsulfinylphenyl)piperidine (0.3 g).

1. temperatureheated
2. temperatureat reflux temperature for 45 minutes
3. temperatureThe reaction mixture was cooled
4. customevaporated
5. additionThe residue was treated with CH2Cl2 (70 mL)
6. additionvia addition of NH4OH solution
7. customThe organic layer was separated
8. dry with materialdried over MgSO4
9. filtrationfiltered
10. customevaporated