Sodium Carbonate → Sodium Ascorbate

HRID 1108035Notes

Reaction equation

HRID 1108035 reaction equation
C[O:2][C:3]([C:5]([C@@H:7]([OH:14])[C@H:8](O)[C@@H:9]([OH:12])[CH2:10][OH:11])=[O:6])=[O:4].C(=O)([O-])[O-].[Na+:19].[Na+]>CO>[O:4]=[C:3]1[O:2][C@H:8]([C@H:9]([CH2:10][OH:11])[OH:12])[C:7]([O-:14])=[C:5]1[OH:6].[Na+:19]

Participants

4

Reactant 2

HCID 10340Sodium CarbonateHCID 200979Methyl 2-keto-L-gulonate

Product 1

HCID 23667548Sodium AscorbateYield 203.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
40 °C

Procedure

208.4 g of methyl 2-keto-L-gulonate are dissolved in 500 g of methanol and the solution is heated to boiling while stirring. 52 g of sodium carbonate are added in the course of 2 hours. The pH value is then 8. The mixture is stirred for 30 minutes, cooled to 40° C. and the precipitated sodium ascorbate is filtered off and washed with 100 g of methanol. The moist sodium ascorbate is dried in a drying oven at 40° C. under reduced pressure. There are obtained about 198.1 g of crude sodium ascorbate with a content of pure sodium ascorbate of about 94%.

Workup

  1. temperaturethe solution is heated
  2. stirringThe mixture is stirred for 30 minutes
  3. filtrationthe precipitated sodium ascorbate is filtered off
  4. washwashed with 100 g of methanol
  5. dry with materialThe moist sodium ascorbate is dried in a drying oven at 40° C. under reduced pressure

Sources & evidence

ORD record
ord-5f41586c0be8420097043b54c8b36db8
Source dataset
uspto-grants-2000_05
Patent number
US06063937

Reaction notes

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