1H-1,2,4-Triazole → HCID 18786635, compound

HRID 1108045Notes

Reaction equation

HRID 1108045 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1([O:20][CH2:19]1)[C:10]([S:13][CH2:14][CH2:15][O:16][CH2:17][CH3:18])([F:12])[F:11].[NH:21]1[CH:25]=[N:24][CH:23]=[N:22]1.C(=O)([O-])[O-].[K+].[K+]>CS(C)=O>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]([OH:20])([CH2:19][N:21]1[CH:25]=[N:24][CH:23]=[N:22]1)[C:10]([S:13][CH2:14][CH2:15][O:16][CH2:17][CH3:18])([F:12])[F:11]

Participants

5

Reactant 3

HCID 92571H-1,2,4-TriazoleHCID 11430Potassium CarbonateHCID 15434384HCID 15434384, compound

Product 1

HCID 18786635HCID 18786635, compoundYield 26.4%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Using 2-(2,4-difluorophenyl)-1-(2-ethyoxyethyl)thio-1,1-difluoro-2,3-epoxypropane (3.1 g, 0.01 mol), DMSO (30 ml), 1,2,4-triazole (1.7 g, 0.025 mol) and potassium carbonate (3.4 g, 0.025 mol), 2-(2,4-difluorophenyl)-1-(2-ethoxyethyl)thio-1,1-difluoro-3-(1H-1,2,4-triazol-1-yl)propan-2-ol (1.0 g, yield: 25.0%) was obtained as colorless crystals by similar procedures to Example 14.

Sources & evidence

ORD record
ord-9c81ac58fec449798913ce8db56618b7
Source dataset
uspto-grants-2000_05
Patent number
US06063945

Reaction notes

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