4-(2-Methylimidazol-1-yl)benzyl chloride hydrochloride → 4-[3-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxamide

HRID 1108085Notes

Reaction equation

HRID 1108085 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([C:8]2([C:14]([NH2:16])=[O:15])[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1.Cl.[CH3:18][C:19]1[N:20]([C:24]2[CH:31]=[CH:30][C:27]([CH2:28]Cl)=[CH:26][CH:25]=2)[CH:21]=[CH:22][N:23]=1>>[CH3:18][C:19]1[N:20]([C:24]2[CH:31]=[CH:30][C:27]([CH2:28][O:1][C:2]3[CH:3]=[C:4]([C:8]4([C:14]([NH2:16])=[O:15])[CH2:13][CH2:12][O:11][CH2:10][CH2:9]4)[CH:5]=[CH:6][CH:7]=3)=[CH:26][CH:25]=2)[CH:21]=[CH:22][N:23]=1

Participants

3

Reactant 2

HCID 187863424-(2-Methylimidazol-1-yl)benzyl chloride hydrochlorideHCID 187863554-(3-Hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxamide

Product 1

HCID 111767984-[3-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxamide

Procedure

4-(3-Hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxamide was reacted with 4-(2-methylimidazol-1-yl)benzyl chloride hydrochloride according to the procedure described in Example 2H to give the titled compound. mp: 183.0-186.0° C.

Sources & evidence

ORD record
ord-fd289874f89946b2815becf91c90ec8b
Source dataset
uspto-grants-2000_05
Patent number
US06063928

Reaction notes

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