HuagongsheHuagongshe Chemistry Print Report · For research reference only
Fumaric Acid → HCID 131721186, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Fumaric Acid | HCID 444972 | — |
| Reactant | 4-(3-{[4-(2-methyl-1H-imidazol-1-yl)phenyl]sulfanyl}phenyl)tetrahydro-2H-pyran-4-carboxamide | HCID 9821945 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 131721186 | HCID 131721186 | 88.6% |
Reaction Steps
4-[3-[4-(2-methylimidazol-1-yl)phenylthio]phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxamide (39 mg, 0.1 mmol) and fumaric acid (12 mg, 0.1 mmol) were dissolved in methanol (3 ml). After stirring for 10 min, volatiles were removed by evaporation and the resulting residue recrystallized from 2-propanol to give the titled compound (40 mg, 78%) as white solids. mp: 183.5-184.9° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06063928 |
| Source dataset | uspto-grants-2000_05 |
| ORD ID | ord-855ba5f813cd40559e43edaf13072765 |
| Source note | uspto-grants-2000_05 |