Phosphorus oxychloride → 2-(4'-Fluorophenyl)-4-chloro-5-methylpyrimidine

HRID 1108205Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:13][C:12](=O)[C:11]([CH3:15])=[CH:10][N:9]=2)=[CH:4][CH:3]=1.P(Cl)(Cl)([Cl:18])=O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([Cl:18])[C:11]([CH3:15])=[CH:10][N:9]=2)=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 187845002-(4'Fluorophenyl)-5-methyl-4-pyrimidinone

Product 1

HCID 187844962-(4'-Fluorophenyl)-4-chloro-5-methylpyrimidine

Procedure

A mixture of 2-(4'-fluorophenyl)-5-methyl-4-pyrimidinone (0.79 g, 3.9 mmol) (from example 5) and phosphorus oxychloride (3 ml) is heated to reflux for 1 hour.

Workup

temperatureis heated
temperatureto reflux for 1 hour

Sources & evidence

ORD record: ord-e7039c64a2ae4d7ca5631831ae4d70af
Source dataset: uspto-grants-2000_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06066597

Reaction notes

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