Acetic Anhydride → 1-(3-Chlorobenzyl)-3-cyanoacetyl-urea

HRID 1108236Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1108236
[C:1]([CH2:3][C:4]([OH:6])=O)#[N:2].C(OC(=O)C)(=O)C.[Cl:14][C:15]1[CH:16]=[C:17]([CH:23]=[CH:24][CH:25]=1)[CH2:18][NH:19][C:20]([NH2:22])=[O:21]>C1COCC1>[Cl:14][C:15]1[CH:16]=[C:17]([CH:23]=[CH:24][CH:25]=1)[CH2:18][NH:19][C:20]([NH:22][C:4](=[O:6])[CH2:3][C:1]#[N:2])=[O:21]

Komponenten

5

Edukt 3

HCID 7918Acetic AnhydrideHCID 9740Cyanoacetic acidHCID 27325773-Chlorobenzylurea

Produkt 1

HCID 184328351-(3-Chlorobenzyl)-3-cyanoacetyl-ureaAusbeute 84,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

3.76 g of 98% cyanoacetic acid and 14 ml of acetic anhydride were heated for 1 hour at 65° C. A solution of 7.73 g of (3-chlorobenzyl)urea in 55 ml THF was added and the mixture kept for 4 hours at 65° C. The THF was removed in vacuo and the residue diluted with 50 ml of toluene. The solid was collected and washed to give the title compound (8.94 g) as a white solid.

Aufarbeitung

  1. customThe THF was removed in vacuo
  2. additionthe residue diluted with 50 ml of toluene
  3. customThe solid was collected
  4. washwashed

Quellen und Nachweise

ORD-Eintrag
ord-397c8cf4ef534260b4fddc7d881abfc0
Quelldatensatz
uspto-grants-2000_05
Patentnummer
US06066641

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