Sodium Hydroxide → 4-(2-Chloro-6-fluorophenyl)-3-cyclopentyloxycarbonyl-1,4-dihydro-2,6-dimethylpyridine-5-carboxylic acid

HRID 1108294Notes

Reaction equation

HRID 1108294 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH:9]1[C:14]([C:15]([O:17][CH:18]2[CH2:22][CH2:21][CH2:20][CH2:19]2)=[O:16])=[C:13]([CH3:23])[NH:12][C:11]([CH3:24])=[C:10]1[C:25]([O:27]CCC#N)=[O:26].[OH-].[Na+]>COCCOC>[CH:18]1([O:17][C:15]([C:14]2[CH:9]([C:3]3[C:4]([F:8])=[CH:5][CH:6]=[CH:7][C:2]=3[Cl:1])[C:10]([C:25]([OH:27])=[O:26])=[C:11]([CH3:24])[NH:12][C:13]=2[CH3:23])=[O:16])[CH2:19][CH2:20][CH2:21][CH2:22]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 187848112-Cyanoethyl cyclopentyl 4-(2-chloro-6-fluorophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate

Product 1

HCID 152854344-(2-Chloro-6-fluorophenyl)-3-cyclopentyloxycarbonyl-1,4-dihydro-2,6-dimethylpyridine-5-carboxylic acid

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

98 g (0.22 mol) of 2-cyanoethyl cyclopentyl 4-(2-chloro-6-fluorophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate are dissolved in 400 ml of 1,2-dimethoxyethane and the solution is stirred with 400 ml of 1 N sodium hydroxide solution at room temperature overnight.

Sources & evidence

ORD record
ord-16aee0a088c845a18f69588b96182922
Source dataset
uspto-grants-2000_05
Patent number
US06066655

Reaction notes

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