HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4-(2-Chloro-6-fluorophenyl)-3-cyclopentyloxycarbonyl-1,4-dihydro-2,6-dimethylpyridine-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-Cyanoethyl cyclopentyl 4-(2-chloro-6-fluorophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate | HCID 18784811 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 4-(2-Chloro-6-fluorophenyl)-3-cyclopentyloxycarbonyl-1,4-dihydro-2,6-dimethylpyridine-5-carboxylic acid | HCID 15285434 | — |
Reaction Steps
98 g (0.22 mol) of 2-cyanoethyl cyclopentyl 4-(2-chloro-6-fluorophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate are dissolved in 400 ml of 1,2-dimethoxyethane and the solution is stirred with 400 ml of 1 N sodium hydroxide solution at room temperature overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06066655 |
| Source dataset | uspto-grants-2000_05 |
| ORD ID | ord-16aee0a088c845a18f69588b96182922 |
| Source note | uspto-grants-2000_05 |