反应详情

Carbon tetrabromide (1.52 g) was added to a stirred solution of (4-bromo-7-methoxybenzofuran-2-yl)-methanol (1 g) in dichloromethane (10 ml) at 0° C. under an inert atmosphere. Triphenylphosphine (1.53 g) was then added and the reaction stirred for 1 h. The reaction mixture was preadsorbed onto silica and purified by column chromatography eluting with 25% ethyl acetate in hexane to afford the title compound as a yellow solid (0.78 g).

1. custompurified by column chromatography
2. washeluting with 25% ethyl acetate in hexane