HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-tert-Butyl-4-methylphenol → 2-Bromo-4-methyl-6-tert-butylphenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-tert-Butyl-4-methylphenol | HCID 17004 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Bromo-4-methyl-6-tert-butylphenol | HCID 10988477 | — |
Reaction Steps
Under nitrogen atmosphere, a dimethylformamide 100 ml solution of N-bromosuccinimide (22.25 g, 125 mmol) was added dropwise at 0° C. to a dimethylformamide 100 ml solution of 2-tert-butyl-4-methylphenol (20.53 g, 125 mmol) with stirring, the resulting reaction mixture was brought up to room temperature and stirred for 5 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06066704 |
| Source dataset | uspto-grants-2000_05 |
| ORD ID | ord-8c1ae205379742eeba247d9b141e0fbb |
| Source note | uspto-grants-2000_05 |