Hydrochloric Acid → HCID 18785143, compound

HRID 1108496Notes

Reaction equation

HRID 1108496 reaction equation
C(OC([N:8]1[C:12]2[C:13]([F:19])=[CH:14][C:15]([NH2:18])=[C:16]([CH3:17])[C:11]=2[N:10]=[CH:9]1)=O)(C)(C)C.[ClH:20]>>[ClH:20].[CH3:17][C:16]1[C:11]2[NH:10][CH:9]=[N:8][C:12]=2[C:13]([F:19])=[CH:14][C:15]=1[NH2:18]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 18785142HCID 18785142, compound

Product 1

HCID 18785143HCID 18785143, compound

Procedure

1-tert-Butoxycarbonyl-4-methyl-5-amino-7-fluorobenzimidazole (1 g) (prepared as described in U.S. Pat. No. 5,478,858 issued to Cupps and Bogdan, Dec. 26, 1995, incorporated herein by reference) and 6N HCl (10 mL) are combined and heated to reflux while stirring. After completion of the t-BOC group deprotection, the reaction mixture is concentrated under reduced pressure and dried to furnish 4methyl-5-amino-7-fluorobenzimidazole hydrochloride.

Workup

  1. temperatureheated
  2. temperatureto reflux
  3. concentrationAfter completion of the t-BOC group deprotection, the reaction mixture is concentrated under reduced pressure
  4. customdried

Sources & evidence

ORD record
ord-25207606004a45c7b45f8040b0f4e281
Source dataset
uspto-grants-2000_05
Patent number
US06066740

Reaction notes

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