Chlorotrimethylsilane → 2-Fluoro-3-(1,4-dioxaspiro[4.5]decan-8-YL)pyrazine

HRID 110854Notes

Reaction equation

HRID 110854 reaction equation
[Br:1][CH2:2][CH2:3][Br:4].[Cl:5][Si:6]([CH3:7])([CH3:8])[CH3:9].[Cu:30][I:31].[F:21][c:22]1[n:23][cH:24][cH:25][n:26][c:27]1[I:28].[I:10][CH:11]1[CH2:12][CH2:13][C:14]2([O:15][CH2:16][CH2:17][O:18]2)[CH2:19][CH2:20]1.[Zn:29]>>[CH:11]1([c:27]2[c:22]([F:21])[n:23][cH:24][cH:25][n:26]2)[CH2:12][CH2:13][C:14]2([O:15][CH2:16][CH2:17][O:18]2)[CH2:19][CH2:20]1

Participants

7

Reactant 6

HCID 6397ChlorotrimethylsilaneHCID 78391,2-DibromoethaneHCID 23994ZincHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 110218798-Iodo-1,4-dioxaspiro[4.5]decaneHCID 153696932-Fluoro-3-iodopyrazine

Product 1

HCID 585479812-Fluoro-3-(1,4-dioxaspiro[4.5]decan-8-YL)pyrazine

Sources & evidence

ORD record
ord-a6d176078a914fcaa05281a45893e61d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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