Trifluoroacetic acid → Trifluoroacetic acid

HRID 1108576Notes

Reaction equation

HRID 1108576 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH3:15])[C:10](=[O:16])[CH2:9]1)=O)(C)(C)C.[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20]>ClCCl>[CH2:14]([N:11]1[CH2:12][CH2:13][NH:8][CH2:9][C:10]1=[O:16])[CH3:15].[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 18783917tert-Butyl 4-ethyl-3-oxopiperazine-1-carboxylate

Product 2

HCID 6422Trifluoroacetic acidHCID 98773661-Ethylpiperazin-2-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-tert-Butoxycarbonyl-4-ethyl-3-oxopiperazine (5.9 g) was dissolved in dichloromethane (100 ml), cooled in an ice-bath, and trifluoroacetic acid (145 ml) added. The mixture was stirred at the same temperature for 2 hours. Solvent was evaporated to yield 1-ethyl-2-oxopiperazine product as a salt with 3 moles of trifluoroacetic acid.

Workup

  1. temperaturecooled in an ice-bath
  2. customSolvent was evaporated

Sources & evidence

ORD record
ord-cf90d9785b894a1ba8a2e5b448e8ef53
Source dataset
uspto-grants-2000_05
Patent number
US06069145

Reaction notes

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