Trifluoroacetic acid → Trifluoroacetic acid

HRID 1108584Notes

Reaction equation

HRID 1108584 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][O:16][CH3:17])[C:10](=[O:18])[CH2:9]1)=O)(C)(C)C.[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22]>ClCCl>[CH3:17][O:16][CH2:15][CH2:14][N:11]1[CH2:12][CH2:13][NH:8][CH2:9][C:10]1=[O:18].[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 18783901tert-Butyl 4-(2-methoxyethyl)-3-oxopiperazine-1-carboxylate

Product 2

HCID 6422Trifluoroacetic acidHCID 187839041-(2-Methoxyethyl)piperazin-2-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-tert-Butoxycarbonyl-4-(2-methoxyethyl)-3-oxopiperazine (6.6 g) was dissolved in dichloromethane (100 ml), the resulting solution cooled in an ice-bath, and trifluoroacetic acid (145 ml) added. The mixture was stirred at the same temperature for 2 hours. Solvent was evaporated to yield 1-(2-methoxyethyl)-2-oxopiperazine product as a salt with 4 moles of trifluoroacetic acid.

Workup

  1. temperaturethe resulting solution cooled in an ice-bath
  2. customSolvent was evaporated

Sources & evidence

ORD record
ord-117ad0c4e71b48be83af6f77d8b15cb8
Source dataset
uspto-grants-2000_05
Patent number
US06069145

Reaction notes

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