Hydrochloric Acid → HCID 178497343, compound

HRID 1108598Notes

Reaction equation

HRID 1108598 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:13]2[NH:17][C:16]3[CH:18]=[CH:19][C:20]([C:22]([O:24][CH3:25])=[O:23])=[CH:21][C:15]=3[N:14]=2)=[C:7]2[C:12]=1[N:11]=[CH:10][CH:9]=[CH:8]2.[ClH:26]>>[ClH:26].[ClH:26].[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:13]2[NH:17][C:16]3[CH:18]=[CH:19][C:20]([C:22]([O:24][CH3:25])=[O:23])=[CH:21][C:15]=3[N:14]=2)=[C:7]2[C:12]=1[N:11]=[CH:10][CH:9]=[CH:8]2

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178497342HCID 178497342, compound

Product 1

HCID 178497343HCID 178497343, compound

Procedure

A sample of 2-(8-methoxyquinolin-5-yl)-1H-benzimidazole-5-carboxylic acid, methyl ester (45 mg) was dissolved in 2M hydrochloric acid (3 ml), the resultant solution filtered and the filtrate concentrated in vacuo. The residue was triturated with dichloromethane and dried in vacuo to provide the title compound as a yellow solid (34 mg).

Workup

  1. filtrationthe resultant solution filtered
  2. concentrationthe filtrate concentrated in vacuo
  3. customThe residue was triturated with dichloromethane
  4. customdried in vacuo

Sources & evidence

ORD record
ord-befc9d43d4dd44a1be8922fceddd1524
Source dataset
uspto-grants-2000_05
Patent number
US06069151

Reaction notes

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